| Ref.No: | 63258400 |
| Start date: | 01.01.2024 |
| End date: | 31.12.2027 |
| Approval date: | 15.12.2023 |
| Department: | CHEMICAL ENGINEERING |
| Sector: | PROCESS ANALYSIS AND PLANT DESIGN |
| Financier: | HORIZON EUROPE, E.C. |
| Budget: | 305.257,50 € |
| Public key: | 9ΥΥΕ46ΨΖΣ4-ΓΘ9 |
| Scientific Responsible: | Prof. SARIMVEIS |
| Email: | hsarimv@central.ntua.gr |
| Description: | THE CHIASMA’S CENTRAL OBJECTIVE IS TO DEVELOP A NEW AND IMPROVED SAFETY AND SUSTAINABLE BY DESIGN ASSESSMENT FRAMEWORK BASED ON INNOVATIVE, IN-PROJECT VALIDATED IN VITRO AND IN SILICO METHODS NEW APPROACH METHODOLOGIES (NAMS) AND DATA FOR THE NEXT GENERATION OF HAZARD- & RISK ASSESSMENT OF CHEMICALS AND MATERIALS. THE DEVELOPED NAMS COVER MAIN HUMAN TARGET ORGANS AND EXPOSURE ROUTES. THE CHIASMA ASSESSMENT FRAMEWORK WILL BE BASED ON AN ITERATIVE MULTI-STEP APPROACH BASED ON NEXT GENARATION SAFETY ASSESSMENT (NGSA) THAT COMBINES CHEMOCENTRIC AND BIOCENTRIC APPROACHES AND NAMS AND IT WILL BE ABLE TO PREDICT REGULATORY RELEVANT ENDPOINTS AND LONG-TERM SAFETY, TOGETHER WITH ABSOLUTE LIFE CYCLE IMPACT ANALYSIS (LCIA). DEVELOPED METHODS WILL BE DEMONSTRATED FOR SCIENFIC SOUNDNESS AND PERFORMANCES AND FOR TRANSFERABILITY (INCLUDING TO INDUSTRIAL ENVIRONMENT), PRIOR TO SUBMISSION TO REGULATORY BODIES. DEMONSTRATION OF THE SSBD FRAMEWORK IN AT LEAST THREE CHEMICALS/MATERIALS GROUPS (PFAS, 2D MATERIALS FOR ENERGY APPLICATIONS AND (NANO-)PESTICIDES) |
