NATURAL DEEP EUTECTIC SOLVENTS (NADES) FOR BIOMEDICAL APPLICATIONS

Ref.No: 61410300
Start date: 02.10.2024
End date: 31.12.2025
Approval date: 02.10.2024
Department: CHEMICAL ENGINEERING
Sector: CHEMICAL SCIENCES
Financier: ΕΠΙΤΕΛΙΚΗ ΔΟΜΗ ΕΣΠΑ, ETHNIKO TAMEIO ANAKAMPSIS KAI ANTHEKTIKOTITAS/UP. PAIDEIAS THRISK & ATHLITISMOU
Budget: 21.542,29 €
Public key: 65ΜΝ46ΨΖΣ4-ΖΑΙ
Scientific Responsible: Prof. ANASTASIA DETSI
Email: adetsi@chemeng.ntua.gr
Description: THE PROJECT FOCUSES ON THE DESIGN, SYNTHESIS AND CHARACTERIZATION OF NEW NATURAL DEEP EUTECTIC SOLVENTS (NADES) AND THEIR USE IN BIOMEDICAL APPLICATIONS. NADES CONSIST OF NATURAL PRODUCTS THAT ACT AS OSMOLYTES, HELPING TO STABILIZE AND TRANSPORT BIOACTIVE SMALL AND LARGE MOLECULAR WEIGHT MOLECULES. THEY ARE BIODEGRADABLE, NON-TOXIC, AND EASY TO SYNTHESIZE. THE PROJECT AIMS TO IMPROVE THE SOLUBILITY AND STABILIZATION OF BIOACTIVE MOLECULES, SUCH AS FLAVONOIDS AND BIOLOGICAL MACROMOLECULES (NUCLEIC ACIDS, PROTEINS), THROUGH THE APPROPRIATE SELECTION OF NADES COMPONENTS. THE METHODOLOGY INCLUDES THE SYNTHESIS, PHYDICOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF NADES AND THE STUDY OF THE STABILITY OF BIOACTIVE MOLECULES IN NADES ENVIRONMENT.
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